Why CBD Works Better with Traces of THC

While CBD and THC both offer therapeutic effects, only the latter causes an intoxicating high. As a consequence, a significant number of people avoid THC in favor of CBD. However, they don’t realize that combining the two could prove more effective than either cannabinoid alone. As long as you get the ratio right, you can mix the two without succumbing to a high.

Let’s examine the science behind why CBD works better with a certain level of THC.

Why Do People Try to Avoid THC?

THC is associated with getting stoned. It is understandable why consumers would try to steer clear. After all, employer drug screenings can uncover THC metabolites. Also, several states allow CBD but not THC. Once you go above the 0.3% THC threshold, you’re breaking the law in these locations. It is also the case where higher THC products come from cannabis rather than hemp. This is also illegal in certain states.

You can purchase full-spectrum CBD and CBD isolate products. The former contains trace amounts of THC, while the latter is almost entirely CBD. There is also broad-spectrum CBD which contains dozens of cannabinoids but zero THC.

Full-spectrum CBD potentially gives you the best of all worlds

Full-spectrum CBD potentially gives you the best of all worlds. It comes from industrial hemp and contains a maximum of 0.3% THC. For the vast majority of users, even the upper end of the limit shouldn’t lead to intoxication. Moreover, you could receive a range of benefits that you may not get from CBD isolate or broad-spectrum products. This is due to a phenomenon known as the entourage effect.

Explaining the Entourage Effect

THC and CBD are just two of over 110 cannabinoids the cannabis plant produces. The best available scientific studies clarify that whole-plant cannabis extracts are superior to single compounds. This is due to the complex mix of cannabinoids, flavonoids, and terpenes, which interact synergistically to produce the entourage effect.

According to this theory, the therapeutic benefits of CBD are possibly amplified by the presence of even a little THC.

Ethan Russo is one of the main champions of the entourage effect. He wrote about it in the British Journal of Pharmacology in 2011 and Frontiers in Plant Science in 2018.

Recent mentions include this study published in Current Neuropharmacology in 2020. The researchers point out that adding terpenes to cannabinoids could help with anxiety and mood disorders.

How do THC & CBD Work Together?

Researchers are still trying to learn more about how CBD, THC, and other cannabinoids, interact with our endocannabinoid system (ECS). We know that THC has a powerful binding affinity with the CB1 receptors in the ECS. Less is known about CBD’s effects. The long-held assumption that CBD has little or no effect on the CB1 receptors is being challenged. It may not bind to CB1 receptors like THC, but it does have an indirect impact, at least.

CBD seems to raise the levels of endocannabinoids, such as anandamide, in the body. The cannabinoid also targets various receptors, such as serotonin and GPR55. It is through these pathways that CBD could help alleviate anxiety, muscle spasms, and other issues.

When you mix CBD and THC, the CBD effectively gets in the way of THC’s attempts to bind with the CB1 receptor. This helps explain why CBD reduces the intoxicating effects of THC.

However, even though they have varying pharmacological properties, they can have similar benefits. What happens is that they act through different mechanisms. For instance, both THC and CBD alone could help relieve pain. However, combine the two, and you could potentially benefit from an even better level of pain relief.

Now, let’s look at research into standalone CBD and when it is mixed with THC.

CBD Is Building an Impressive ‘Résumé’

CBD has shown promise for its powerful antipsychotic properties in human trials of treatment-resistant schizophrenia.

Furthermore, in May 2017, a clinical trial tested the effects of CBD on the debilitating epileptic condition, Dravet’s Syndrome. The study found that CBD reduced seizures by half in 43% of subjects who received the medication. The trial helped prompt the FDA to approve a CBD oral solution known as Epidiolex, predominantly for seizure cases, in June 2018.

CBD is also considered an option for depression, anxiety, pain, diabetes, neurodegenerative disease, addiction, head trauma, and many more conditions.

For instance, a 2015 study in Neurotherapeutics found that CBD was potentially useful in helping with anxiety disorders. A study published in The Permanente Journal in 2019 discovered that CBD helped fight insomnia and reduced anxiety.

The list of positive results from CBD studies is growing quickly, and the cannabinoid’s track record is promising. However, there is also plenty of evidence that mixing CBD with THC has many benefits.

What Research Says About Combining CBD and THC

According to multiple studies, CBD is more effective when used together with THC. Here’s an overview of a few relevant studies.

• A 2010 study looked at the combination of CBD and THC on patients with intractable cancer-related pain. The researchers found that patients could tolerate the mix better than a pure THC extract.
• A 2012 study for the Journal of Psychopharmacology reported that CBD inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.
• A study published in Frontiers in Pharmacology in 2019 looked at how THC and CBD worked together in zebrafish models of neuro-hyperactivity. The researchers looked at several CBD: THC ratios and found that 1:1 was the most effective.